Modifications in Bone Matrix of Estrogen-Deficient Rats Treated with Intermittent PTH

Modifications in Bone Matrix of Estrogen-Deficient Rats Treated with Intermittent PTH

Bone matrix dictates strength, elasticity, and stiffness to the bone. Intermittent parathyroid hormone (iPTH), a bone-forming treatment, is widely used as a therapy for osteoporosis. We investigate whether low doses of intermittent PTH (1-34) change the profile of organic components in the bone matrix after 30 days of treatment. Forty 6-month-old female Wistar rats underwent ovariectomy and aft...

Atrophic femoral bone nonunion treated with 1-84 PTH.

Prolonged Treatments With Antiresorptive Agents and PTH Have Different Effects on Bone Strength and the Degree of Mineralization in Old Estrogen-Deficient Osteoporotic Rats

Current approved medical treatments for osteoporosis reduce fracture risk to a greater degree than predicted from change in BMD in women with postmenopausal osteoporosis. We hypothesize that bone active agents improve bone strength in osteoporotic bone by altering different material properties of the bone. Eighteen-month-old female Fischer rats were ovariectomized (OVX) or sham-operated and lef...

determinant of the hankel matrix with binomial entries

abstract in this thesis at first we comput the determinant of hankel matrix with enteries a_k (x)=?_(m=0)^k??((2k+2-m)¦(k-m)) x^m ? by using a new operator, ? and by writing and solving differential equation of order two at points x=2 and x=-2 . also we show that this determinant under k-binomial transformation is invariant.

Intermittent PTH Treatment Rescues Impaired Fracture and Bone Graft Healing with Aging

INTRODUCTION Aging decreases chondrogenesis, bone formation, callus vascularization and remodeling during facture healing in mice, which is associated with reduced cyclooxygenase-2 (COX-2) expression, and is restored by administration of an EP4 agonist. Activation of the EP4 receptor stimulates cAMP and activation of the protein kinase A (PKA) signaling pathway. These findings suggest that enha...